Nice job NPR..keep up the great investigative journalism..

That spurred my biochemical motors into action, and with a bit of brute force and biochemistry knowledge our lab came up with a great alternative to the guanosine quenching. The alternative is terrific because it could work with any underlying sequence...a patent was filed, and today SIMPLEPROBEs are available for genotyping applications.  If your real-time PCR machine can do a SYBR Green I melt, you can do SIMPLEPROBE genotyping. 

If you already use SIMPLEPROBES, we make the best in the country you should give us a try.  If you want to use SIMPLEPROBEs try out our Design Confirmation Service and you will be amazed at how easy they are to use.  All of these can be found on our Fluoresentric Store at store.fluoresentric.com

I remember a few years back when I spent some time with the folks form Caliper as they were bringing their Swinger online with the Roche 480 platform. That real-time instrument combined with a robotic arm was sure a sight to see.

Now if sample preparation could enter the dawning age of rapid diagnostics that would be something, at Fluoresentric we have been working on automation friendly sample preparation chemistries.  One that we know works really well with automation is the Direct-2-PCR chemistry, it is only a few pipetting steps for a robot, though we do it with dropper vials in our lower throughput, and field deployed settings.  Furthermore, there is only limited additional equipment required, and most liquid handling robots can do what is needed...heat the sample.

If you want to try it out for yourself we are offering a buy 1 get 1 free offer now through the end of May. Check us out online at www.fluoresentric.com or go directly to the product page at Direct-2-PCR.